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Crystal structure of perakine reductase, founder member of a novel akr subfamily with unique conformational changes during NADPH binding

Analyse Crystal structure of perakine reductase, founder member of a novel akr… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3UYI
Type: protein
Length: 313 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Perakine reductase
UniProt: Q3L181
Pockets: 3 · best druggability 0.66

Structure

x-ray diffraction · 1 distinct chain · 40% helix, 21% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Perakine reductase	protein	313	40% helix, 21% strand	Q3L181

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	579	0.66	0.76	57	empty
2	73	0.32	0.75	21	empty
3	56	0.28	0.73	14	empty

Modifications

Observed in the structure: 1 modified (methylation).

Compared structures

3UYI · Crystal Structure of Perakine Reductase, Founder Member of a Novel AKR Subfamily with… · the same entry in another collection · chain A against A, TM-score 1.00
Q3L181 · AlphaFold monomer V2.0 prediction for perakine reductase (Q3L181) · a predicted model of the same protein · chain A against A, TM-score 0.89

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q3L181
Elsewhere: RCSB PDB 3UYI · PDBe 3UYI · UniProt Q3L181

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