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The structure of the catalytic domain of the sulfolobus spindle-shaped viral integrase reveals an evolutionarily conserved catalytic core and supports a mechanism of DNA cleavage in trans

Analyse The structure of the catalytic domain of the sulfolobus spindle-shaped viral… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3UXU
Type: protein
Length: 159 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Probable integrase
UniProt: P20214
Ligands: PO4
Pockets: 1 · best druggability 0.31

Structure

x-ray diffraction · 1 distinct chain · 58% helix, 11% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Probable integrase	protein	159	58% helix, 11% strand	P20214

Ligands and binding sites

PO4 · Phosphate ion · ion · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	77	0.31	0.73	13	empty

Modifications

Observed in the structure: 1 disulfide (disulfide).

Compared structures

3UXU · The structure of the catalytic domain of the Sulfolobus Spindle-shaped viral integrase… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P20214
Elsewhere: RCSB PDB 3UXU · PDBe 3UXU · UniProt P20214

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