Research workbench

Crystal structure of rat DNA polymerase beta, wild type apoenzyme

Analyse Crystal structure of rat DNA polymerase beta, wild type apoenzyme in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3UXN
Type: protein
Length: 650 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: DNA polymerase beta
EC: 2.7.7.7, 4.2.99.-
UniProt: P06766
Pockets: 4 · best druggability 0.79

Structure

x-ray diffraction · 1 distinct chain · 47% helix, 13% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	DNA polymerase beta (EC 2.7.7.7, 4.2.99.-)	protein	325	47% helix, 13% strand	P06766

Pockets

4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	130	0.79	0.97	18	empty
2	617	0.65	0.75	63	empty
3	79	0.34	0.75	17	empty
4	111	0.32	0.72	21	empty

Interfaces

1 interface between chains.

A–B · 511 Å² buried · 8 hydrogen bonds · protein-protein

Compared structures

3UXN · Crystal Structure of Rat DNA Polymerase Beta, Wild Type Apoenzyme · the same entry in another collection · chain A against A, TM-score 1.00
P06766 · AlphaFold monomer V2.0 prediction for DNA polymerase beta (P06766) · a predicted model of the same protein · chain B against A, TM-score 0.73

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P06766
Elsewhere: RCSB PDB 3UXN · PDBe 3UXN · UniProt P06766

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.