Research workbench
Structural insights into a human anti-ifn antibody exerting therapeutic potential for systemic lupus erythematosus
Analyse Structural insights into a human anti-ifn antibody exerting therapeutic… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3UX9
- Type
- protein
- Length
- 720 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Interferon alpha-1/13; Scfv antibody
- UniProt
- P01562
- Pockets
- 6 · best druggability 0.78
Structure
x-ray diffraction · 4 distinct chains · 30% helix, 32% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Interferon alpha-1/13 | protein | 132 | 73% helix, 0% strand | P01562 |
| B | Scfv antibody | protein | 229 | 5% helix, 51% strand | — |
| C | Interferon alpha-1/13 | protein | 129 | 74% helix, 0% strand | P01562 |
| D | Scfv antibody | protein | 230 | 5% helix, 50% strand | — |
Pockets
6 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 955 | 0.78 | 0.81 | 87 | empty |
| 2 | 355 | 0.64 | 0.79 | 31 | empty |
| 3 | 128 | 0.42 | 0.76 | 20 | empty |
| 4 | 108 | 0.41 | 0.77 | 17 | empty |
| 5 | 64 | 0.30 | 0.75 | 18 | empty |
Interfaces
4 interfaces between chains.
- A–B · 921 Ų buried · 20 hydrogen bonds · protein-protein
- C–D · 914 Ų buried · 18 hydrogen bonds · protein-protein
- A–D · 561 Ų buried · 2 hydrogen bonds · protein-protein
- B–D · 280 Ų buried · 4 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 6 disulfide (disulfide).
Compared structures
- 3UX9 · Structural insights into a human anti-IFN antibody exerting therapeutic potential for… · the same entry in another collection · chain A against A, TM-score 1.00
- P01562 · AlphaFold monomer V2.0 prediction for interferon alpha-1/13 (P01562) · a predicted model of the same protein · chain C against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P01562
- Elsewhere: RCSB PDB 3UX9 · PDBe 3UX9 · UniProt P01562
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