Research workbench
Crystal structure of the periplasmic sugar binding protein chve
Analyse Crystal structure of the periplasmic sugar binding protein chve in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3UUG
- Type
- protein
- Length
- 658 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Multiple sugar-binding periplasmic receptor chve
- UniProt
- P25548
- Ligands
- BDP
- Pockets
- 4 · best druggability 0.74
Structure
x-ray diffraction · 1 distinct chain · 46% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Multiple sugar-binding periplasmic receptor chve | protein | 329 | 46% helix, 16% strand | P25548 |
Ligands and binding sites
- BDP · beta-D-glucopyranuronic acid · sugar · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 743 | 0.74 | 0.80 | 61 | empty |
| 2 | 795 | 0.70 | 0.76 | 81 | empty |
| 3 | 73 | 0.65 | 0.92 | 24 | BDP |
| 4 | 55 | 0.32 | 0.77 | 16 | empty |
Interfaces
1 interface between chains.
- A–B · 892 Ų buried · 15 hydrogen bonds · protein-protein
Compared structures
- 3UUG · Crystal structure of the periplasmic sugar binding protein ChvE · the same entry in another collection · chain A against A, TM-score 1.00
- P25548 · AlphaFold monomer V2.0 prediction for multiple sugar-binding periplasmic receptor chve… · a predicted model of the same protein · chain B against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P25548
- Elsewhere: RCSB PDB 3UUG · PDBe 3UUG · UniProt P25548
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