Research workbench
Structure of the intracellular kinase homology domain of RV3910 at 2.2 a resolution
Analyse Structure of the intracellular kinase homology domain of RV3910 at 2.2 a… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3UQC
- Type
- protein
- Length
- 989 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Probable conserved transmembrane protein
- UniProt
- O05435
- Pockets
- 11 · best druggability 0.69
Structure
x-ray diffraction · 4 distinct chains · 36% helix, 22% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Probable conserved transmembrane protein | protein | 246 | 35% helix, 23% strand | O05435 |
| B | Probable conserved transmembrane protein | protein | 244 | 36% helix, 22% strand | O05435 |
| C | Probable conserved transmembrane protein | protein | 250 | 36% helix, 22% strand | O05435 |
| D | Probable conserved transmembrane protein | protein | 249 | 36% helix, 21% strand | O05435 |
Ligands and binding sites
- SIN · Succinic acid · additive · chains B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
11 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 642 | 0.69 | 0.77 | 48 | empty |
| 2 | 539 | 0.66 | 0.77 | 47 | empty |
| 3 | 245 | 0.52 | 0.76 | 31 | empty |
| 4 | 117 | 0.43 | 0.77 | 27 | empty |
| 5 | 113 | 0.42 | 0.77 | 27 | empty |
Interfaces
4 interfaces between chains.
- B–C · 641 Ų buried · 11 hydrogen bonds · protein-protein
- A–D · 602 Ų buried · 15 hydrogen bonds · protein-protein
- C–D · 201 Ų buried · 2 hydrogen bonds · protein-protein
- A–C · 60 Ų buried · 1 hydrogen bond · protein-protein
Compared structures
- 3UQC · Structure of the Intracellular Kinase Homology Domain of Rv3910 at 2.2 A resolution · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O05435
- Elsewhere: RCSB PDB 3UQC · PDBe 3UQC · UniProt O05435
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