Research workbench
Crystal structure of the anti-activator rapf complexed with the response regulator coma DNA binding domain
Analyse Crystal structure of the anti-activator rapf complexed with the response… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3ULQ
- Type
- protein
- Length
- 434 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Response regulator aspartate phosphatase F; Transcriptional regulatory protein coma
- EC
- 3.1.-.-
- UniProt
- P71002, P14204
- Ligands
- MN
- Pockets
- 4 · best druggability 0.61
Structure
x-ray diffraction · 2 distinct chains · 79% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Response regulator aspartate phosphatase F (EC 3.1.-.-) | protein | 376 | 81% helix, 0% strand | P71002 |
| B | Transcriptional regulatory protein coma | protein | 58 | 71% helix, 0% strand | P14204 |
Ligands and binding sites
- MN · Manganese (II) ion · metal · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 459 | 0.61 | 0.75 | 44 | empty |
| 2 | 95 | 0.43 | 0.78 | 19 | empty |
| 3 | 62 | 0.32 | 0.76 | 17 | empty |
| 4 | 67 | 0.30 | 0.74 | 11 | empty |
Interfaces
1 interface between chains.
- A–B · 979 Ų buried · 16 hydrogen bonds · protein-protein
Compared structures
- 3ULQ · Crystal Structure of the Anti-Activator RapF Complexed with the Response Regulator ComA… · the same entry in another collection · chain A against A, TM-score 1.00
- P14204 · AlphaFold monomer V2.0 prediction for transcriptional regulatory protein coma (P14204) · a predicted model of the same protein · chain B against A, TM-score 0.95
- P71002 · AlphaFold monomer V2.0 prediction for response regulator aspartate phosphatase F (P71002) · a predicted model of the same protein · chain A against A, TM-score 0.68
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P71002
- Every structure of UniProt P14204
- Elsewhere: RCSB PDB 3ULQ · PDBe 3ULQ · UniProt P71002 · UniProt P14204
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