Research workbench
Crystal structure of the human two pore domain potassium ion channel K2P1 (twik-1)
Analyse Crystal structure of the human two pore domain potassium ion channel K2P1… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3UKM
- Type
- protein
- Length
- 1,008 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Potassium channel subfamily K member 1
- UniProt
- O00180
- Ligands
- K
- Pockets
- 4 · best druggability 0.77
Structure
x-ray diffraction · 1 distinct chain · 73% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D | Potassium channel subfamily K member 1 | protein | 252 | 73% helix, 0% strand | O00180 |
Ligands and binding sites
- K · Potassium ion · metal · 10 copies · chains A, B, C, D
- UND · Undecane · additive · 4 copies · chains A, B, C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 816 | 0.77 | 0.80 | 62 | UND |
| 2 | 784 | 0.76 | 0.80 | 62 | UND |
| 3 | 804 | 0.72 | 0.78 | 73 | K |
| 4 | 757 | 0.72 | 0.78 | 65 | K |
Interfaces
2 interfaces between chains.
- A–B · 2588 Ų buried · 14 hydrogen bonds · protein-protein
- C–D · 2576 Ų buried · 12 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
- 3UKM · Crystal structure of the human two pore domain potassium ion channel K2P1 (TWIK-1) · the same entry in another collection · chain A against A, TM-score 1.00
- O00180 · AlphaFold monomer V2.0 prediction for potassium channel subfamily K member 1 (O00180) · a predicted model of the same protein · chain A against A, TM-score 0.79
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O00180
- Elsewhere: RCSB PDB 3UKM · PDBe 3UKM · UniProt O00180
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