Research workbench
Solution structure of apo groel by cryo-electron microscopy
Analyse Solution structure of apo groel by cryo-electron microscopy in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1GR5
- Type
- protein
- Length
- 7,238 residues
- Chains
- 14
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 60 kda chaperonin
- UniProt
- P0A6F6
- Pockets
- 20 · best druggability 0.81
Structure
electron microscopy · 1 distinct chain · 51% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F, G, H, I, J, K, L, M, N | 60 kda chaperonin | protein | 517 | 51% helix, 16% strand | P0A6F6 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 964 | 0.81 | 0.83 | 100 | empty |
| 2 | 799 | 0.80 | 0.84 | 87 | empty |
| 3 | 888 | 0.80 | 0.83 | 85 | empty |
| 4 | 954 | 0.80 | 0.82 | 93 | empty |
| 5 | 754 | 0.79 | 0.83 | 78 | empty |
Interfaces
28 interfaces between chains.
- H–I · 1990 Ų buried · 35 hydrogen bonds · protein-protein
- H–N · 1988 Ų buried · 35 hydrogen bonds · protein-protein
- I–J · 1988 Ų buried · 35 hydrogen bonds · protein-protein
- M–N · 1987 Ų buried · 35 hydrogen bonds · protein-protein
- J–K · 1985 Ų buried · 35 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 7 isopeptide (isopeptide).
Compared structures
- 1GR5 · Solution Structure of apo GroEL by Cryo-Electron microscopy · the same entry in another collection · chain K against K, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0A6F6
- Elsewhere: RCSB PDB 1GR5 · PDBe 1GR5 · UniProt P0A6F6
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