Structural and functional characterization of an anesthetic binding site in the second cysteine-rich domain of protein kinase C delta

Structure

x-ray diffraction · 1 distinct chain · 9% helix, 35% strand (DSSP).

Ligands and binding sites

• 09V · cyclopropylmethanol · ligand · 2 copies · chains A, B
• ZN · Zinc ion · metal · 4 copies · chains A, B
• PO4 · Phosphate ion · ion · 3 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Interfaces

1 interface between chains.

• A–B · 452 Ų buried · 15 hydrogen bonds · protein-protein

Compared structures

• 3UGL · Structural and functional characterization of an anesthetic binding site in the second… · the same entry in another collection · chain A against A, TM-score 1.00
• P28867 · AlphaFold monomer V2.0 prediction for protein kinase C delta type (P28867) · a predicted model of the same protein · chain A against A, TM-score 0.77

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P28867
• Elsewhere: RCSB PDB 3UGL · PDBe 3UGL · UniProt P28867