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Guanylate kinase domains of the maguk family scaffold proteins as specific phospho-protein binding modules
Analyse Guanylate kinase domains of the maguk family scaffold proteins as specific… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3UAT
- Type
- protein
- Length
- 291 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Disks large homolog 1; Phosphor-lgn peptide
- UniProt
- Q62696
- Pockets
- 2 · best druggability 0.62
Structure
x-ray diffraction · 2 distinct chains · 32% helix, 25% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Disks large homolog 1 | protein | 276 | 32% helix, 26% strand | Q62696 |
| B | Phosphor-lgn peptide | protein | 15 | 27% helix, 13% strand | — |
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 396 | 0.62 | 0.77 | 49 | empty |
| 2 | 183 | 0.47 | 0.76 | 26 | empty |
Interfaces
1 interface between chains.
- A–B · 841 Ų buried · 15 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 modified (phosphorylation).
Compared structures
- 3UAT · Guanylate Kinase Domains of the MAGUK Family Scaffold Proteins as Specific… · the same entry in another collection · chain A against A, TM-score 1.00
- Q62696 · AlphaFold monomer V2.0 prediction for disks large homolog 1 (Q62696) · a predicted model of the same protein · chain A against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q62696
- Elsewhere: RCSB PDB 3UAT · PDBe 3UAT · UniProt Q62696
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