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Crystal structure of human menin

Analyse Crystal structure of human menin in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3U84
Type: protein
Length: 978 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Menin
UniProt: O00255
Pockets: 11 · best druggability 0.72

Structure

x-ray diffraction · 2 distinct chains · 55% helix, 7% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Menin	protein	506	55% helix, 7% strand	O00255
B	Menin	protein	472	55% helix, 7% strand	O00255

Pockets

11 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	709	0.72	0.78	69	empty
2	674	0.67	0.76	53	empty
3	82	0.39	0.78	21	empty
4	79	0.36	0.76	18	empty
5	87	0.33	0.74	15	empty

Interfaces

1 interface between chains.

A–B · 194 Å² buried · 0 hydrogen bonds · protein-protein

Compared structures

3U84 · Crystal Structure of Human Menin · the same entry in another collection · chain A against A, TM-score 1.00
O00255 · AlphaFold monomer V2.0 prediction for menin (O00255) · a predicted model of the same protein · chain B against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O00255
Elsewhere: RCSB PDB 3U84 · PDBe 3U84 · UniProt O00255

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