Research workbench
Crystal structure of the KRIT1/CCM1 ferm domain in complex with the heart of glass (HEG1) cytoplasmic tail
Analyse Crystal structure of the KRIT1/CCM1 ferm domain in complex with the heart of… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3U7D
- Type
- protein
- Length
- 623 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Krev interaction trapped protein 1; Protein heg homolog 1
- UniProt
- O00522, Q9ULI3
- Pockets
- 7 · best druggability 0.83
Structure
x-ray diffraction · 3 distinct chains · 34% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C | Krev interaction trapped protein 1 | protein | 305 | 36% helix, 24% strand | O00522 |
| B | Protein heg homolog 1 | protein | 7 | 0% helix, 0% strand | Q9ULI3 |
| D | Protein heg homolog 1 | protein | 6 | 0% helix, 0% strand | Q9ULI3 |
Pockets
7 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 364 | 0.83 | 0.92 | 43 | empty |
| 2 | 203 | 0.62 | 0.83 | 36 | empty |
| 3 | 200 | 0.60 | 0.82 | 32 | empty |
| 4 | 168 | 0.42 | 0.73 | 29 | empty |
| 5 | 52 | 0.38 | 0.80 | 16 | empty |
Interfaces
3 interfaces between chains.
- A–C · 1231 Ų buried · 23 hydrogen bonds · protein-protein
- A–B · 579 Ų buried · 4 hydrogen bonds · protein-protein
- C–D · 570 Ų buried · 8 hydrogen bonds · protein-protein
Compared structures
- 3U7D · Crystal structure of the KRIT1/CCM1 FERM domain in complex with the heart of glass (HEG1)… · the same entry in another collection · chain A against A, TM-score 1.00
- O00522 · AlphaFold monomer V2.0 prediction for krev interaction trapped protein 1 (O00522) · a predicted model of the same protein · chain A against A, TM-score 0.98
- Q9ULI3 · AlphaFold monomer V2.0 prediction for protein heg homolog 1 (Q9ULI3) · a predicted model of the same protein · chain D against A, TM-score 0.69
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O00522
- Every structure of UniProt Q9ULI3
- Elsewhere: RCSB PDB 3U7D · PDBe 3U7D · UniProt O00522 · UniProt Q9ULI3
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