Research workbench
Truncated M. tuberculosis leua (1-425) complexed with kiv
Analyse Truncated M. tuberculosis leua (1-425) complexed with kiv in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3U6W
- Type
- protein
- Length
- 804 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 2-isopropylmalate synthase
- EC
- 2.3.3.13
- UniProt
- P96420
- Ligands
- KIV, MN
- Pockets
- 13 · best druggability 0.85
Structure
x-ray diffraction · 2 distinct chains · 44% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | 2-isopropylmalate synthase (EC 2.3.3.13) | protein | 399 | 44% helix, 15% strand | P96420 |
| B | 2-isopropylmalate synthase (EC 2.3.3.13) | protein | 405 | 43% helix, 15% strand | P96420 |
Ligands and binding sites
- KIV · 3-methyl-2-oxobutanoic acid · ligand · 2 copies · chains A, B
- MN · Manganese (II) ion · metal · 2 copies · chains A, B
- GOL · Glycerol · additive · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
13 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 288 | 0.85 | 0.96 | 42 | GOL |
| 2 | 128 | 0.78 | 0.97 | 31 | empty |
| 3 | 118 | 0.78 | 0.97 | 27 | empty |
| 4 | 191 | 0.73 | 0.90 | 43 | empty |
| 5 | 63 | 0.71 | 0.97 | 24 | empty |
Interfaces
1 interface between chains.
- A–B · 5917 Ų buried · 92 hydrogen bonds · protein-protein
Compared structures
- 3U6W · Truncated M. tuberculosis LeuA (1-425) complexed with KIV · the same entry in another collection · chain B against B, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P96420
- Elsewhere: RCSB PDB 3U6W · PDBe 3U6W · UniProt P96420
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