Research workbench
N-terminal 81-aa fragment of smooth muscle tropomyosin alpha
Analyse N-terminal 81-aa fragment of smooth muscle tropomyosin alpha in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3U1A
- Type
- protein
- Length
- 330 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Smooth muscle tropomyosin alpha
- UniProt
- P04268
- Pockets
- 1 · best druggability 0.54
Structure
x-ray diffraction · 3 distinct chains · 97% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Smooth muscle tropomyosin alpha | protein | 82 | 98% helix, 0% strand | P04268 |
| B, C | Smooth muscle tropomyosin alpha | protein | 84 | 95% helix, 0% strand | P04268 |
| D | Smooth muscle tropomyosin alpha | protein | 80 | 98% helix, 0% strand | P04268 |
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 307 | 0.54 | 0.75 | 30 | empty |
Interfaces
4 interfaces between chains.
- A–B · 1883 Ų buried · 11 hydrogen bonds · protein-protein
- C–D · 1869 Ų buried · 12 hydrogen bonds · protein-protein
- B–C · 339 Ų buried · 3 hydrogen bonds · protein-protein
- A–C · 298 Ų buried · 8 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P04268
- Elsewhere: RCSB PDB 3U1A · PDBe 3U1A · UniProt P04268
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