Research workbench
The pleckstrin homology (pH) domain of USP37
Analyse The pleckstrin homology (pH) domain of USP37 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3U12
- Type
- protein
- Length
- 207 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- USP37 protein
- UniProt
- Q86W68
- Ligands
- UNX, SO4
- Pockets
- 1 · best druggability 0.42
Structure
x-ray diffraction · 2 distinct chains · 14% helix, 55% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | USP37 protein | protein | 104 | 14% helix, 56% strand | Q86W68 |
| B | USP37 protein | protein | 103 | 15% helix, 54% strand | Q86W68 |
Ligands and binding sites
- UNX · Unknown atom or ion · ion · 29 copies · chains A, B
- SO4 · Sulfate ion · ion · 4 copies · chains A, B
- ACT · Acetate ion · additive · 2 copies · chains A, B
- EDO · 1,2-ethanediol · additive · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 93 | 0.42 | 0.78 | 17 | EDO |
Interfaces
1 interface between chains.
- A–B · 864 Ų buried · 13 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 5 modified (engineered).
Compared structures
- 3U12 · The pleckstrin homology (PH) domain of USP37 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q86W68
- Elsewhere: RCSB PDB 3U12 · PDBe 3U12 · UniProt Q86W68
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