Research workbench
ATP-dependent protease hslv from bacillus anthracis str. ames
Analyse ATP-dependent protease hslv from bacillus anthracis str. ames in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3TY6
- Type
- protein
- Length
- 1,066 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- ATP-dependent protease subunit hslv
- EC
- 3.4.25.2
- UniProt
- Q81WK5
- Ligands
- SO4
- Pockets
- 8 · best druggability 0.67
Structure
x-ray diffraction · 2 distinct chains · 36% helix, 29% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, D, E, F | ATP-dependent protease subunit hslv (EC 3.4.25.2) | protein | 178 | 37% helix, 29% strand | Q81WK5 |
| C | ATP-dependent protease subunit hslv (EC 3.4.25.2) | protein | 176 | 36% helix, 28% strand | Q81WK5 |
Ligands and binding sites
- SO4 · Sulfate ion · ion · 6 copies · chains A, B, C, E, F
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
8 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 606 | 0.67 | 0.77 | 77 | empty |
| 2 | 370 | 0.63 | 0.78 | 49 | empty |
| 3 | 452 | 0.62 | 0.76 | 65 | empty |
| 4 | 141 | 0.57 | 0.83 | 23 | empty |
| 5 | 131 | 0.51 | 0.80 | 21 | empty |
Interfaces
7 interfaces between chains.
- D–E · 843 Ų buried · 11 hydrogen bonds · protein-protein
- C–E · 832 Ų buried · 5 hydrogen bonds · protein-protein
- E–F · 821 Ų buried · 9 hydrogen bonds · protein-protein
- B–C · 810 Ų buried · 7 hydrogen bonds · protein-protein
- B–D · 799 Ų buried · 2 hydrogen bonds · protein-protein
Compared structures
- 3TY6 · ATP-dependent Protease HslV from Bacillus anthracis str. Ames · the same entry in another collection · chain F against F, TM-score 1.00
- Q81WK5 · AlphaFold monomer V2.0 prediction for ATP-dependent protease subunit hslv (Q81WK5) · a predicted model of the same protein · chain C against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q81WK5
- Elsewhere: RCSB PDB 3TY6 · PDBe 3TY6 · UniProt Q81WK5
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