Research workbench
Gef domain of dennd 1B in complex with rab GTPase RAB35
Analyse Gef domain of dennd 1B in complex with rab GTPase RAB35 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3TW8
- Type
- protein
- Length
- 1,047 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Denn domain-containing protein 1B; RAS-related protein rab-35
- UniProt
- Q15286
- Pockets
- 13 · best druggability 0.76
Structure
x-ray diffraction · 4 distinct chains · 42% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Denn domain-containing protein 1B | protein | 343 | 45% helix, 17% strand | — |
| B | RAS-related protein rab-35 | protein | 169 | 38% helix, 28% strand | Q15286 |
| C | Denn domain-containing protein 1B | protein | 362 | 43% helix, 17% strand | — |
| D | RAS-related protein rab-35 | protein | 173 | 38% helix, 28% strand | Q15286 |
Pockets
13 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 563 | 0.76 | 0.83 | 47 | empty |
| 2 | 435 | 0.68 | 0.80 | 49 | empty |
| 3 | 323 | 0.65 | 0.80 | 25 | empty |
| 4 | 276 | 0.55 | 0.77 | 26 | empty |
| 5 | 104 | 0.55 | 0.84 | 18 | empty |
Interfaces
3 interfaces between chains.
- C–D · 1577 Ų buried · 25 hydrogen bonds · protein-protein
- A–B · 1496 Ų buried · 22 hydrogen bonds · protein-protein
- A–C · 674 Ų buried · 11 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q15286
- Elsewhere: RCSB PDB 3TW8 · PDBe 3TW8 · UniProt Q15286
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