Research workbench
Crystal structure of farnesyl diphosphate synthase (target efi-501951) from methylococcus capsulatus
Analyse Crystal structure of farnesyl diphosphate synthase (target efi-501951) from… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3TS7
- Type
- protein
- Length
- 586 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Geranyltranstransferase
- EC
- 2.5.1.10
- UniProt
- Q60AN0
- Ligands
- PO4
- Pockets
- 9 · best druggability 0.72
Structure
x-ray diffraction · 2 distinct chains · 72% helix, 1% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Geranyltranstransferase (EC 2.5.1.10) | protein | 289 | 70% helix, 1% strand | Q60AN0 |
| B | Geranyltranstransferase (EC 2.5.1.10) | protein | 297 | 74% helix, 1% strand | Q60AN0 |
Ligands and binding sites
- PO4 · Phosphate ion · ion · 5 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
9 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 566 | 0.72 | 0.80 | 58 | PO4 |
| 2 | 510 | 0.71 | 0.80 | 53 | PO4 |
| 3 | 53 | 0.63 | 0.94 | 14 | empty |
| 4 | 115 | 0.41 | 0.76 | 18 | empty |
| 5 | 113 | 0.38 | 0.75 | 19 | empty |
Interfaces
1 interface between chains.
- A–B · 1687 Ų buried · 11 hydrogen bonds · protein-protein
Compared structures
- 3TS7 · CRYSTAL STRUCTURE OF FARNESYL DIPHOSPHATE SYNTHASE (TARGET EFI-501951) FROM Methylococcus… · the same entry in another collection · chain B against B, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q60AN0
- Elsewhere: RCSB PDB 3TS7 · PDBe 3TS7 · UniProt Q60AN0
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