Research workbench
Structure of the dimethyladenosine transferase (ksga) from coxiella burnetii
Analyse Structure of the dimethyladenosine transferase (ksga) from coxiella burnetii in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3TQS
- Type
- protein
- Length
- 988 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ribosomal RNA small subunit methyltransferase a
- EC
- 2.1.1.182
- UniProt
- Q83AC2
- Pockets
- 7 · best druggability 0.71
Structure
x-ray diffraction · 1 distinct chain · 41% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D | Ribosomal RNA small subunit methyltransferase a (EC 2.1.1.182) | protein | 247 | 41% helix, 21% strand | Q83AC2 |
Pockets
7 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 360 | 0.71 | 0.83 | 46 | empty |
| 2 | 389 | 0.71 | 0.82 | 50 | empty |
| 3 | 350 | 0.70 | 0.83 | 47 | empty |
| 4 | 237 | 0.65 | 0.83 | 41 | empty |
| 5 | 77 | 0.45 | 0.81 | 16 | empty |
Interfaces
3 interfaces between chains.
- B–C · 406 Ų buried · 6 hydrogen bonds · protein-protein
- A–D · 406 Ų buried · 4 hydrogen bonds · protein-protein
- A–B · 403 Ų buried · 3 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 12 modified (engineered).
Compared structures
- 3TQS · Structure of the dimethyladenosine transferase (ksgA) from Coxiella burnetii · the same entry in another collection · chain A against A, TM-score 1.00
- Q83AC2 · AlphaFold monomer V2.0 prediction for ribosomal RNA small subunit methyltransferase a… · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q83AC2
- Elsewhere: RCSB PDB 3TQS · PDBe 3TQS · UniProt Q83AC2
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