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Microcin C7 self immunity protein mccf mutant W186F in complex with adenosine monophosphate

Analyse Microcin C7 self immunity protein mccf mutant W186F in complex with adenosine… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3TLZ
Type: protein
Length: 670 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Mccf
UniProt: Q2KKH9
Ligands: AMP
Pockets: 5 · best druggability 0.67

Structure

x-ray diffraction · 1 distinct chain · 31% helix, 23% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Mccf	protein	335	31% helix, 23% strand	Q2KKH9

Ligands and binding sites

AMP · Adenosine monophosphate · ligand · 2 copies · chains A, B
EDO · 1,2-ethanediol · additive · 6 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	615	0.67	0.77	80	AMP
2	184	0.56	0.80	27	EDO
3	106	0.56	0.84	23	EDO
4	52	0.32	0.77	11	EDO
5	50	0.29	0.75	11	EDO

Interfaces

1 interface between chains.

A–B · 1909 Å² buried · 42 hydrogen bonds · protein-protein

Compared structures

3TLZ · Microcin C7 self immunity protein MccF mutant W186F in complex with Adenosine… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q2KKH9
Elsewhere: RCSB PDB 3TLZ · PDBe 3TLZ · UniProt Q2KKH9

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