Research workbench

Microcin C7 self immunity protein mccf in the wild type apo state

Analyse Microcin C7 self immunity protein mccf in the wild type apo state in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3TLA
Type: protein
Length: 670 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Mccf
UniProt: Q2KKH9
Pockets: 6 · best druggability 0.60

Structure

x-ray diffraction · 1 distinct chain · 31% helix, 23% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Mccf	protein	335	31% helix, 23% strand	Q2KKH9

Ligands and binding sites

EDO · 1,2-ethanediol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

6 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	85	0.60	0.88	20	EDO
2	292	0.57	0.77	43	empty
3	270	0.56	0.77	36	empty
4	93	0.55	0.85	25	empty
5	55	0.31	0.75	11	empty

Interfaces

1 interface between chains.

A–B · 1886 Å² buried · 43 hydrogen bonds · protein-protein

Compared structures

3TLA · Microcin C7 self immunity protein MccF in the wild type APO state · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q2KKH9
Elsewhere: RCSB PDB 3TLA · PDBe 3TLA · UniProt Q2KKH9

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