Research workbench
Crystal structure of full-length human peroxiredoxin 4 with mixed conformation
Analyse Crystal structure of full-length human peroxiredoxin 4 with mixed conformation in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3TKQ
- Type
- protein
- Length
- 873 residues
- Chains
- 5
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Peroxiredoxin-4
- EC
- 1.11.1.15
- UniProt
- Q13162
- Pockets
- 4 · best druggability 0.45
Structure
x-ray diffraction · 4 distinct chains · 29% helix, 27% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Peroxiredoxin-4 (EC 1.11.1.15) | protein | 191 | 28% helix, 26% strand | Q13162 |
| B | Peroxiredoxin-4 (EC 1.11.1.15) | protein | 185 | 27% helix, 26% strand | Q13162 |
| C, E | Peroxiredoxin-4 (EC 1.11.1.15) | protein | 166 | 30% helix, 28% strand | Q13162 |
| D | Peroxiredoxin-4 (EC 1.11.1.15) | protein | 165 | 32% helix, 28% strand | Q13162 |
Pockets
4 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 73 | 0.45 | 0.82 | 21 | empty |
| 2 | 69 | 0.44 | 0.81 | 17 | empty |
| 3 | 63 | 0.43 | 0.82 | 16 | empty |
| 4 | 64 | 0.39 | 0.79 | 15 | empty |
Interfaces
2 interfaces between chains.
- A–E · 64 Ų buried · 0 hydrogen bonds · protein-protein
- A–B · 43 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 3TKQ · Crystal structure of full-length human peroxiredoxin 4 with mixed conformation · the same entry in another collection · chain E against E, TM-score 1.00
- Q13162 · AlphaFold monomer V2.0 prediction for peroxiredoxin-4 (Q13162) · a predicted model of the same protein · chain D against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q13162
- Elsewhere: RCSB PDB 3TKQ · PDBe 3TKQ · UniProt Q13162
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