Research workbench
Tryptophan synthase subunit alpha from campylobacter jejuni.
Analyse Tryptophan synthase subunit alpha from campylobacter jejuni. in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3THA
- Type
- protein
- Length
- 497 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Tryptophan synthase alpha chain
- EC
- 4.2.1.20
- UniProt
- Q9PIF1
- Pockets
- 8 · best druggability 0.86
Structure
x-ray diffraction · 2 distinct chains · 45% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Tryptophan synthase alpha chain (EC 4.2.1.20) | protein | 248 | 45% helix, 16% strand | Q9PIF1 |
| B | Tryptophan synthase alpha chain (EC 4.2.1.20) | protein | 249 | 45% helix, 16% strand | Q9PIF1 |
Pockets
8 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 373 | 0.86 | 0.94 | 51 | empty |
| 2 | 312 | 0.74 | 0.86 | 48 | empty |
| 3 | 396 | 0.72 | 0.83 | 45 | empty |
| 4 | 126 | 0.57 | 0.83 | 20 | empty |
| 5 | 54 | 0.52 | 0.87 | 13 | empty |
Interfaces
1 interface between chains.
- A–B · 1878 Ų buried · 17 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 8 modified (engineered).
Compared structures
- 3THA · Tryptophan synthase subunit alpha from Campylobacter jejuni. · the same entry in another collection · chain A against A, TM-score 1.00
- Q9PIF1 · AlphaFold monomer V2.0 prediction for tryptophan synthase alpha chain (Q9PIF1) · a predicted model of the same protein · chain A against A, TM-score 0.94
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9PIF1
- Elsewhere: RCSB PDB 3THA · PDBe 3THA · UniProt Q9PIF1
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.