Research workbench
1.8 ångström resolution crystal structure of K135M mutant of transaldolase B (tala) from francisella tularensis in complex with fructose 6-phosphate
Analyse 1.8 ångström resolution crystal structure of K135M mutant of transaldolase B… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3TE9
- Type
- protein
- Length
- 623 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Transaldolase
- EC
- 2.2.1.2
- UniProt
- Q5NFX0
- Ligands
- F6R, PO4
- Pockets
- 5 · best druggability 0.87
Structure
x-ray diffraction · 2 distinct chains · 58% helix, 13% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Transaldolase (EC 2.2.1.2) | protein | 310 | 57% helix, 13% strand | Q5NFX0 |
| B | Transaldolase (EC 2.2.1.2) | protein | 313 | 58% helix, 12% strand | Q5NFX0 |
Ligands and binding sites
- F6R · Fructose -6-phosphate · ligand · chains A
- PO4 · Phosphate ion · ion · chains B
- PGE · Triethylene glycol · additive · 6 copies · chains A, B
- PEG · Di(hydroxyethyl)ether · additive · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 254 | 0.87 | 0.99 | 28 | empty |
| 2 | 184 | 0.54 | 0.79 | 32 | PO4 |
| 3 | 161 | 0.53 | 0.80 | 34 | F6R |
| 4 | 65 | 0.28 | 0.73 | 12 | empty |
| 5 | 52 | 0.25 | 0.73 | 11 | PGE |
Interfaces
1 interface between chains.
- A–B · 852 Ų buried · 7 hydrogen bonds · protein-protein
Compared structures
- 3TE9 · 1.8 Angstrom Resolution Crystal Structure of K135M Mutant of Transaldolase B (TalA) from… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q5NFX0
- Elsewhere: RCSB PDB 3TE9 · PDBe 3TE9 · UniProt Q5NFX0
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