Research workbench
Coiled-coil oligomerization domain of the polycystin transient receptor potential channel PKD2L1
Analyse Coiled-coil oligomerization domain of the polycystin transient receptor… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3TE3
- Type
- protein
- Length
- 211 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Polycystic kidney disease 2-like 1 protein
- UniProt
- Q9P0L9
- Pockets
- 2 · best druggability 0.52
Structure
x-ray diffraction · 5 distinct chains · 80% helix, 2% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, D | Polycystic kidney disease 2-like 1 protein | protein | 34 | 82% helix, 0% strand | Q9P0L9 |
| B | Polycystic kidney disease 2-like 1 protein | protein | 35 | 83% helix, 0% strand | Q9P0L9 |
| C | Polycystic kidney disease 2-like 1 protein | protein | 37 | 78% helix, 0% strand | Q9P0L9 |
| E | Polycystic kidney disease 2-like 1 protein | protein | 33 | 76% helix, 6% strand | Q9P0L9 |
| F | Polycystic kidney disease 2-like 1 protein | protein | 38 | 82% helix, 5% strand | Q9P0L9 |
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 199 | 0.52 | 0.77 | 21 | empty |
| 2 | 75 | 0.33 | 0.75 | 16 | empty |
Interfaces
11 interfaces between chains.
- D–F · 712 Ų buried · 4 hydrogen bonds · protein-protein
- E–F · 699 Ų buried · 3 hydrogen bonds · protein-protein
- D–E · 683 Ų buried · 4 hydrogen bonds · protein-protein
- A–B · 664 Ų buried · 3 hydrogen bonds · protein-protein
- B–C · 610 Ų buried · 2 hydrogen bonds · protein-protein
Compared structures
- 3TE3 · Coiled-coil oligomerization domain of the polycystin transient receptor potential channel… · the same entry in another collection · chain F against F, TM-score 1.00
- Q9P0L9 · AlphaFold monomer V2.0 prediction for polycystic kidney disease 2-like 1 protein (Q9P0L9) · a predicted model of the same protein · chain A against A, TM-score 0.86
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9P0L9
- Elsewhere: RCSB PDB 3TE3 · PDBe 3TE3 · UniProt Q9P0L9
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