Research workbench

Tyrosine aminotransferase from E. COLI

Analyse Tyrosine aminotransferase from E. COLI in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3TAT
Type: protein
Length: 2,382 residues
Chains: 6
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Tyrosine aminotransferase
EC: 2.6.1.57
UniProt: P04693
Ligands: PLP
Pockets: 20 · best druggability 0.75

Structure

x-ray diffraction · 1 distinct chain · 41% helix, 7% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D, E, F	Tyrosine aminotransferase (EC 2.6.1.57)	protein	397	41% helix, 7% strand	P04693

Ligands and binding sites

PLP · Pyridoxal-5'-phosphate · ligand · 6 copies · chains A, B, C, D, E, F

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	269	0.75	0.88	47	empty
2	190	0.74	0.89	32	empty
3	174	0.74	0.90	30	empty
4	273	0.73	0.87	43	empty
5	179	0.73	0.90	30	empty

Interfaces

4 interfaces between chains.

A–B · 3066 Å² buried · 43 hydrogen bonds · protein-protein
E–F · 2971 Å² buried · 40 hydrogen bonds · protein-protein
C–D · 2941 Å² buried · 39 hydrogen bonds · protein-protein
A–E · 439 Å² buried · 6 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 6 cofactor (pyridoxal phosphate Schiff base).

Compared structures

3TAT · Tyrosine aminotransferase from E. COLI · the same entry in another collection · chain A against A, TM-score 1.00
P04693 · AlphaFold monomer V2.0 prediction for aromatic-amino-acid aminotransferase (P04693) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P04693
Elsewhere: RCSB PDB 3TAT · PDBe 3TAT · UniProt P04693

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.