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Crystal structure of the TAZ2:C/EBPEPSILON-tad chimera protein

Analyse Crystal structure of the TAZ2:C/EBPEPSILON-tad chimera protein in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB
3T92
Type
protein
Length
113 residues
Chains
1
Method
x-ray diffraction
Collection
MolNFT v1 / PDB
Contract
0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner
0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule
Histone acetyltransferase P300 TAZ2-CCAAT/ENHANCER-binding protein epsilon
EC
2.3.1.48
UniProt
Q09472, Q15744
Ligands
TCE, TAM, ACN, ZN

Structure

x-ray diffraction · 1 distinct chain · 70% helix, 0% strand (DSSP).

ChainMoleculeTypeResiduesSecondary structureUniProt
AHistone acetyltransferase P300 TAZ2-CCAAT/ENHANCER-binding protein epsilon (EC 2.3.1.48)protein11370% helix, 0% strandQ09472, Q15744

Ligands and binding sites

  • TCE · 3,3',3''-phosphanetriyltripropanoic acid · ligand · chains A
  • TAM · Tris(hydroxyethyl)aminomethane · ligand · chains A
  • ACN · Acetone · ligand · chains A
  • ZN · Zinc ion · metal · 3 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

  • 3T92 · Crystal structure of the Taz2:C/EBPepsilon-TAD chimera protein · the same entry in another collection · chain A against A, TM-score 1.00
  • Q09472 · AlphaFold monomer V2.0 prediction for histone acetyltransferase P300 (Q09472) · a predicted model of the same protein · chain A against A, TM-score 0.83
  • Q15744 · AlphaFold monomer V2.0 prediction for CCAAT/ENHANCER-binding protein epsilon (Q15744) · a predicted model of the same protein · chain A against A, TM-score 0.33

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