Research workbench
ATG8 transfer from ATG7 to ATG3: a distinctive E1-E2 architecture and mechanism in the autophagy pathway
Analyse ATG8 transfer from ATG7 to ATG3: a distinctive E1-E2 architecture and mechanism… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3T7H
- Type
- protein
- Length
- 568 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ubiquitin-like modifier-activating enzyme ATG7
- UniProt
- P38862
- Pockets
- 5 · best druggability 0.78
Structure
x-ray diffraction · 2 distinct chains · 26% helix, 35% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Ubiquitin-like modifier-activating enzyme ATG7 | protein | 280 | 26% helix, 36% strand | P38862 |
| B | Ubiquitin-like modifier-activating enzyme ATG7 | protein | 288 | 26% helix, 35% strand | P38862 |
Pockets
5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 750 | 0.78 | 0.82 | 95 | empty |
| 2 | 71 | 0.52 | 0.85 | 16 | empty |
| 3 | 75 | 0.50 | 0.84 | 15 | empty |
| 4 | 111 | 0.44 | 0.78 | 22 | empty |
| 5 | 139 | 0.44 | 0.76 | 26 | empty |
Interfaces
1 interface between chains.
- A–B · 953 Ų buried · 6 hydrogen bonds · protein-protein
Compared structures
- 3T7H · Atg8 transfer from Atg7 to Atg3: a distinctive E1-E2 architecture and mechanism in the… · the same entry in another collection · chain A against A, TM-score 1.00
- P38862 · AlphaFold monomer V2.0 prediction for ubiquitin-like modifier- activating enzyme ATG7… · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P38862
- Elsewhere: RCSB PDB 3T7H · PDBe 3T7H · UniProt P38862
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