Research workbench

ATG8 transfer from ATG7 to ATG3: a distinctive E1-E2 architecture and mechanism in the autophagy pathway

Analyse ATG8 transfer from ATG7 to ATG3: a distinctive E1-E2 architecture and mechanism… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3T7F
Type: protein
Length: 291 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Ubiquitin-like modifier-activating enzyme ATG7
UniProt: P38862
Pockets: 4 · best druggability 0.44

Structure

x-ray diffraction · 1 distinct chain · 26% helix, 34% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Ubiquitin-like modifier-activating enzyme ATG7	protein	291	26% helix, 34% strand	P38862

Pockets

4 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	138	0.44	0.76	26	empty
2	98	0.40	0.76	19	empty
3	73	0.35	0.77	14	empty
4	83	0.32	0.74	18	empty

Modifications

Observed in the structure: 3 modified (engineered).

Compared structures

3T7F · Atg8 transfer from Atg7 to Atg3: a distinctive E1-E2 architecture and mechanism in the… · the same entry in another collection · chain A against A, TM-score 1.00
P38862 · AlphaFold monomer V2.0 prediction for ubiquitin-like modifier- activating enzyme ATG7… · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P38862
Elsewhere: RCSB PDB 3T7F · PDBe 3T7F · UniProt P38862

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.