Research workbench
Structure of the E. COLI ssb-DNA polymerase III interface
Analyse Structure of the E. COLI ssb-DNA polymerase III interface in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3SXU
- Type
- protein
- Length
- 252 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- DNA polymerase III subunit chi; DNA polymerase III subunit psi; Ssb peptide
- EC
- 2.7.7.7
- UniProt
- P28905, P28632
- Pockets
- 2 · best druggability 0.50
Structure
x-ray diffraction · 3 distinct chains · 34% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | DNA polymerase III subunit chi (EC 2.7.7.7) | protein | 146 | 32% helix, 23% strand | P28905 |
| B | DNA polymerase III subunit psi (EC 2.7.7.7) | protein | 102 | 39% helix, 18% strand | P28632 |
| C | Ssb peptide | protein | 4 | 0% helix, 0% strand | — |
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 104 | 0.50 | 0.82 | 22 | empty |
| 2 | 76 | 0.31 | 0.74 | 16 | empty |
Interfaces
2 interfaces between chains.
- A–B · 769 Ų buried · 10 hydrogen bonds · protein-protein
- A–C · 302 Ų buried · 4 hydrogen bonds · protein-protein
Compared structures
- 3SXU · Structure of the E. coli SSB-DNA polymerase III interface · the same entry in another collection · chain A against A, TM-score 1.00
- P28632 · AlphaFold monomer V2.0 prediction for DNA polymerase III subunit psi (P28632) · a predicted model of the same protein · chain B against A, TM-score 0.99
- P28905 · AlphaFold monomer V2.0 prediction for DNA polymerase III subunit chi (P28905) · a predicted model of the same protein · chain A against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P28905
- Every structure of UniProt P28632
- Elsewhere: RCSB PDB 3SXU · PDBe 3SXU · UniProt P28905 · UniProt P28632
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