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Mycobacterium tuberculosis eis protein initiates modulation of host immune responses by acetylation of DUSP16/MKP-7

Analyse Mycobacterium tuberculosis eis protein initiates modulation of host immune… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3SXO
Type: protein
Length: 792 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Enhanced intracellular survival protein
UniProt: P71727
Pockets: 7 · best druggability 0.88

Structure

x-ray diffraction · 1 distinct chain · 29% helix, 32% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Enhanced intracellular survival protein	protein	396	29% helix, 32% strand	P71727

Pockets

7 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	914	0.88	0.90	84	empty
2	492	0.77	0.85	65	empty
3	1182	0.76	0.79	103	empty
4	103	0.63	0.88	22	empty
5	83	0.55	0.86	23	empty

Interfaces

1 interface between chains.

A–B · 2031 Å² buried · 29 hydrogen bonds · protein-protein

Compared structures

3SXO · Mycobacterium tuberculosis Eis protein initiates modulation of host immune responses by… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P71727
Elsewhere: RCSB PDB 3SXO · PDBe 3SXO · UniProt P71727

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