Research workbench
Structure of the regulatory complex of escherichia COLI iiiglc with glycerol kinase
Analyse Structure of the regulatory complex of escherichia COLI iiiglc with glycerol… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1GLB
- Type
- protein
- Length
- 650 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Glucose-specific protein iiiglc; Glycerol kinase
- EC
- 2.7.1.69, 2.7.1.30
- UniProt
- P69783, P0A6F3
- Ligands
- ADP
- Pockets
- 7 · best druggability 0.66
Structure
x-ray diffraction · 2 distinct chains · 28% helix, 28% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| F | Glucose-specific protein iiiglc (EC 2.7.1.69) | protein | 161 | 12% helix, 40% strand | P69783 |
| G | Glycerol kinase (EC 2.7.1.30) | protein | 489 | 33% helix, 24% strand | P0A6F3 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
7 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 384 | 0.66 | 0.79 | 45 | ADP, GOL |
| 2 | 340 | 0.61 | 0.78 | 36 | empty |
| 3 | 151 | 0.60 | 0.84 | 25 | empty |
| 4 | 53 | 0.42 | 0.82 | 13 | empty |
| 5 | 82 | 0.37 | 0.77 | 26 | empty |
Interfaces
1 interface between chains.
- F–G · 697 Ų buried · 3 hydrogen bonds · protein-protein
Compared structures
- 1GLB · Structure of the regulatory complex of escherichia COLI iiiglc with glycerol kinase · the same entry in another collection · chain F against F, TM-score 1.00
- P0A6F3 · AlphaFold monomer V2.0 prediction for glycerol kinase (P0A6F3) · a predicted model of the same protein · chain G against A, TM-score 0.98
- P69783 · AlphaFold monomer V2.0 prediction for pts system glucose-specific eiia component (P69783) · a predicted model of the same protein · chain F against A, TM-score 0.92
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P69783
- Every structure of UniProt P0A6F3
- Elsewhere: RCSB PDB 1GLB · PDBe 1GLB · UniProt P69783 · UniProt P0A6F3
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