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Crystal structure of an endosomal snare core complex

Analyse Crystal structure of an endosomal snare core complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB
1GL2
Type
protein
Length
229 residues
Chains
4
Method
x-ray diffraction
Collection
MolNFT v1 / PDB
Contract
0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner
0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule
Endobrevin; Syntaxin 7; Vesicle transport V-snare protein VTI1-like 1; Syntaxin 8
UniProt
Q9WUF4, O70439, O88384, Q9Z2Q7

Structure

x-ray diffraction · 4 distinct chains · 94% helix, 0% strand (DSSP).

ChainMoleculeTypeResiduesSecondary structureUniProt
AEndobrevinprotein5494% helix, 0% strandQ9WUF4
BSyntaxin 7protein6095% helix, 0% strandO70439
CVesicle transport V-snare protein VTI1-like 1protein6093% helix, 0% strandO88384
DSyntaxin 8protein5595% helix, 0% strandQ9Z2Q7

Interfaces

6 interfaces between chains.

  • B–C · 1452 Ų buried · 13 hydrogen bonds · protein-protein
  • A–B · 1396 Ų buried · 7 hydrogen bonds · protein-protein
  • A–D · 1262 Ų buried · 9 hydrogen bonds · protein-protein
  • C–D · 1234 Ų buried · 14 hydrogen bonds · protein-protein
  • B–D · 399 Ų buried · 0 hydrogen bonds · protein-protein

Compared structures

  • 1GL2 · Crystal structure of an endosomal SNARE core complex · the same entry in another collection · chain D against D, TM-score 1.00
  • Q9Z2Q7 · AlphaFold monomer V2.0 prediction for syntaxin-8 (Q9Z2Q7) · a predicted model of the same protein · chain D against A, TM-score 0.92
  • O88384 · AlphaFold monomer V2.0 prediction for vesicle transport through interaction with T-snares… · a predicted model of the same protein · chain C against A, TM-score 0.92
  • Q9WUF4 · AlphaFold monomer V2.0 prediction for vesicle-associated membrane protein 8 (Q9WUF4) · a predicted model of the same protein · chain A against A, TM-score 0.90
  • O70439 · AlphaFold monomer V2.0 prediction for syntaxin-7 (O70439) · a predicted model of the same protein · chain B against A, TM-score 0.79

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