Research workbench
Crystal structure of mouse glutaminase C, L-glutamate-bound form
Analyse Crystal structure of mouse glutaminase C, L-glutamate-bound form in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3SS5
- Type
- protein
- Length
- 1,571 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Glutaminase C
- EC
- 3.5.1.2
- UniProt
- Q69ZX9
- Ligands
- GLU
- Pockets
- 10 · best druggability 0.76
Structure
x-ray diffraction · 4 distinct chains · 49% helix, 12% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Glutaminase C (EC 3.5.1.2) | protein | 394 | 50% helix, 12% strand | Q69ZX9 |
| B | Glutaminase C (EC 3.5.1.2) | protein | 390 | 49% helix, 12% strand | Q69ZX9 |
| C | Glutaminase C (EC 3.5.1.2) | protein | 396 | 49% helix, 12% strand | Q69ZX9 |
| D | Glutaminase C (EC 3.5.1.2) | protein | 391 | 49% helix, 12% strand | Q69ZX9 |
Ligands and binding sites
- GLU · Glutamic acid · ligand · 4 copies · chains A, B, C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
10 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1027 | 0.76 | 0.79 | 120 | GLU |
| 2 | 993 | 0.75 | 0.78 | 108 | GLU |
| 3 | 376 | 0.71 | 0.83 | 42 | empty |
| 4 | 375 | 0.69 | 0.82 | 42 | empty |
| 5 | 99 | 0.37 | 0.75 | 17 | empty |
Interfaces
4 interfaces between chains.
- B–C · 1704 Ų buried · 23 hydrogen bonds · protein-protein
- A–D · 1687 Ų buried · 24 hydrogen bonds · protein-protein
- C–D · 494 Ų buried · 3 hydrogen bonds · protein-protein
- A–B · 470 Ų buried · 1 hydrogen bond · protein-protein
Compared structures
- 3SS5 · Crystal structure of mouse Glutaminase C, L-glutamate-bound form · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q69ZX9
- Elsewhere: RCSB PDB 3SS5 · PDBe 3SS5 · UniProt Q69ZX9
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