Research workbench
Crystal structure of mouse glutaminase C, ligand-free form
Analyse Crystal structure of mouse glutaminase C, ligand-free form in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3SS3
- Type
- protein
- Length
- 1,552 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Glutaminase C
- EC
- 3.5.1.2
- UniProt
- Q69ZX9
- Ligands
- CL
- Pockets
- 12 · best druggability 0.74
Structure
x-ray diffraction · 4 distinct chains · 50% helix, 11% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Glutaminase C (EC 3.5.1.2) | protein | 394 | 51% helix, 12% strand | Q69ZX9 |
| B | Glutaminase C (EC 3.5.1.2) | protein | 390 | 50% helix, 11% strand | Q69ZX9 |
| C | Glutaminase C (EC 3.5.1.2) | protein | 383 | 49% helix, 11% strand | Q69ZX9 |
| D | Glutaminase C (EC 3.5.1.2) | protein | 385 | 49% helix, 11% strand | Q69ZX9 |
Ligands and binding sites
- CL · Chloride ion · ion · 4 copies · chains A, B, C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
12 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1094 | 0.74 | 0.77 | 125 | CL |
| 2 | 661 | 0.70 | 0.78 | 91 | CL |
| 3 | 389 | 0.69 | 0.82 | 43 | empty |
| 4 | 365 | 0.68 | 0.81 | 44 | empty |
| 5 | 113 | 0.39 | 0.75 | 18 | empty |
Interfaces
4 interfaces between chains.
- A–C · 1700 Ų buried · 25 hydrogen bonds · protein-protein
- B–D · 1683 Ų buried · 25 hydrogen bonds · protein-protein
- A–D · 548 Ų buried · 2 hydrogen bonds · protein-protein
- B–C · 511 Ų buried · 3 hydrogen bonds · protein-protein
Compared structures
- 3SS3 · Crystal structure of mouse Glutaminase C, ligand-free form · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q69ZX9
- Elsewhere: RCSB PDB 3SS3 · PDBe 3SS3 · UniProt Q69ZX9
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