Research workbench

Squalene-hopene cyclase

Analyse Squalene-hopene cyclase in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3SQC
Type: protein
Length: 1,857 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Squalene--hopene cyclase
EC: 5.4.99.-
UniProt: P33247
Pockets: 20 · best druggability 0.87

Structure

x-ray diffraction · 1 distinct chain · 53% helix, 4% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C	Squalene--hopene cyclase (EC 5.4.99.-)	protein	619	53% helix, 4% strand	P33247

Pockets

20 pockets found on a 1 Å grid, 10 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	531	0.87	0.92	71	empty
2	405	0.86	0.94	54	empty
3	406	0.86	0.94	54	empty
4	83	0.74	0.96	17	empty
5	75	0.73	0.96	17	empty

Interfaces

3 interfaces between chains.

B–C · 554 Å² buried · 1 hydrogen bond · protein-protein
A–B · 549 Å² buried · 7 hydrogen bonds · protein-protein
A–C · 533 Å² buried · 4 hydrogen bonds · protein-protein

Compared structures

3SQC · Squalene-hopene cyclase · the same entry in another collection · chain A against A, TM-score 1.00
P33247 · AlphaFold monomer V2.0 prediction for squalene--hopene cyclase (P33247) · a predicted model of the same protein · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P33247
Elsewhere: RCSB PDB 3SQC · PDBe 3SQC · UniProt P33247

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.