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Inward rectifier potassium channel KIR2.2 in complex with dioctanoylglycerol pyrophosphate (dgpp)

Analyse Inward rectifier potassium channel KIR2.2 in complex with dioctanoylglycerol… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3SPC
Type: protein
Length: 327 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Inward-rectifier K+ channel KIR2.2
UniProt: D2YW45
Ligands: P8P, K
Pockets: 3 · best druggability 0.43

Structure

x-ray diffraction · 1 distinct chain · 33% helix, 28% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Inward-rectifier K+ channel KIR2.2	protein	327	33% helix, 28% strand	D2YW45

Ligands and binding sites

P8P · (2R)-3-{[(R)-hydroxy(phosphonooxy)phosphoryl]oxy}propane-1,2-diyl dioctanoate · ligand · chains A
K · Potassium ion · metal · 6 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	131	0.43	0.76	25	empty
2	84	0.33	0.74	23	empty
3	54	0.30	0.75	13	empty

Modifications

Observed in the structure: 1 disulfide (disulfide).

Compared structures

3SPC · Inward rectifier potassium channel Kir2.2 in complex with dioctanoylglycerol… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt D2YW45
Elsewhere: RCSB PDB 3SPC · PDBe 3SPC · UniProt D2YW45

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