Research workbench
Crystal structure of phenazine resistance protein ehpr from enterobacter agglomerans (erwinia herbicola, pantoea agglomerans) EH1087 in complex with griseoluteic acid
Analyse Crystal structure of phenazine resistance protein ehpr from enterobacter… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3SK2
- Type
- protein
- Length
- 264 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ehpr
- UniProt
- Q8GPH6
- Ligands
- GRI
- Pockets
- 2 · best druggability 0.71
Structure
x-ray diffraction · 1 distinct chain · 19% helix, 35% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Ehpr | protein | 132 | 19% helix, 35% strand | Q8GPH6 |
Ligands and binding sites
- GRI · 6-formyl-9-methoxyphenazine-1-carboxylic acid · ligand · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 59 | 0.71 | 0.98 | 24 | empty |
| 2 | 100 | 0.47 | 0.80 | 19 | GRI |
Interfaces
1 interface between chains.
- A–B · 2254 Ų buried · 30 hydrogen bonds · protein-protein
Compared structures
- 3SK2 · Crystal structure of phenazine resistance protein EhpR from Enterobacter agglomerans… · the same entry in another collection · chain A against A, TM-score 1.00
- Q8GPH6 · AlphaFold monomer V2.0 prediction for phenazine antibiotic resistance protein ehpr… · a predicted model of the same protein · chain B against A, TM-score 0.93
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8GPH6
- Elsewhere: RCSB PDB 3SK2 · PDBe 3SK2 · UniProt Q8GPH6
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