Research workbench
Crystal structure of the C147A mutant 3C from enterovirus 71
Analyse Crystal structure of the C147A mutant 3C from enterovirus 71 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3SJK
- Type
- protein
- Length
- 186 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 3C protease; Kpvlrtatvqgpsldf peptide
- EC
- 3.4.22.28
- UniProt
- E0WWC7
- Pockets
- 2 · best druggability 0.38
Structure
x-ray diffraction · 2 distinct chains · 11% helix, 55% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | 3C protease (EC 3.4.22.28) | protein | 179 | 11% helix, 55% strand | E0WWC7 |
| B | Kpvlrtatvqgpsldf peptide | protein | 7 | 0% helix, 57% strand | — |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 79 | 0.38 | 0.77 | 15 | empty |
| 2 | 59 | 0.30 | 0.75 | 13 | empty |
Interfaces
1 interface between chains.
- A–B · 402 Ų buried · 8 hydrogen bonds · protein-protein
Compared structures
- 3SJK · Crystal structure of the C147A mutant 3C from enterovirus 71 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt E0WWC7
- Elsewhere: RCSB PDB 3SJK · PDBe 3SJK · UniProt E0WWC7
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