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Crystal structure of the C147A mutant 3C of CVA16 in complex with faglrqavtq peptide

Analyse Crystal structure of the C147A mutant 3C of CVA16 in complex with faglrqavtq… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3SJ9
Type: protein
Length: 187 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: 3C protease; Faglrqavtq peptide
EC: 3.4.22.28
UniProt: C8CIL7
Pockets: 1 · best druggability 0.36

Structure

x-ray diffraction · 2 distinct chains · 10% helix, 55% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	3C protease (EC 3.4.22.28)	protein	179	11% helix, 55% strand	C8CIL7
B	Faglrqavtq peptide	protein	8	0% helix, 50% strand	—

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	67	0.36	0.76	12	empty

Interfaces

1 interface between chains.

A–B · 550 Å² buried · 20 hydrogen bonds · protein-protein

Compared structures

3SJ9 · crystal structure of the C147A mutant 3C of CVA16 in complex with FAGLRQAVTQ peptide · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt C8CIL7
Elsewhere: RCSB PDB 3SJ9 · PDBe 3SJ9 · UniProt C8CIL7

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