Research workbench
Tandem repeat of amyloid-related segment of alphab-crystallin residues 90-100 mutant V91L
Analyse Tandem repeat of amyloid-related segment of alphab-crystallin residues 90-100… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3SGR
- Type
- protein
- Length
- 149 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Tandem repeat of amyloid-related segment of alphab- crystallin residues 90-100 mutant V91L
- UniProt
- P02511
- Pockets
- 2 · best druggability 0.47
Structure
x-ray diffraction · 2 distinct chains · 0% helix, 82% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, D, E, F | Tandem repeat of amyloid-related segment of alphab- crystallin residues 90-100 mutant V91L | protein | 25 | 0% helix, 80% strand | P02511 |
| C | Tandem repeat of amyloid-related segment of alphab- crystallin residues 90-100 mutant V91L | protein | 24 | 0% helix, 83% strand | P02511 |
Ligands and binding sites
- MPD · (4S)-2-methyl-2,4-pentanediol · additive · 2 copies · chains A, D, E, F, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 108 | 0.47 | 0.79 | 15 | MPD |
| 2 | 73 | 0.31 | 0.74 | 19 | empty |
Interfaces
12 interfaces between chains.
- A–C · 537 Ų buried · 8 hydrogen bonds · protein-protein
- A–D · 476 Ų buried · 9 hydrogen bonds · protein-protein
- E–F · 465 Ų buried · 6 hydrogen bonds · protein-protein
- C–D · 455 Ų buried · 9 hydrogen bonds · protein-protein
- B–E · 444 Ų buried · 8 hydrogen bonds · protein-protein
Compared structures
- 3SGR · Tandem repeat of amyloid-related segment of alphaB-crystallin residues 90-100 mutant V91L · the same entry in another collection · chain F against F, TM-score 1.00
- P02511 · AlphaFold monomer V2.0 prediction for alpha-crystallin B chain (P02511) · a predicted model of the same protein · chain B against A, TM-score 0.37
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P02511
- Elsewhere: RCSB PDB 3SGR · PDBe 3SGR · UniProt P02511
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.