Research workbench
Crystal structure of tax-interacting protein-1 (tip-1) PDZ domain bound to ICAL36 inhibitor peptide
Analyse Crystal structure of tax-interacting protein-1 (tip-1) PDZ domain bound to… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3SFJ
- Type
- protein
- Length
- 227 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- TAX1-binding protein 3; Decameric peptide ICAL36
- UniProt
- O14907
- Pockets
- 1 · best druggability 0.40
Structure
x-ray diffraction · 3 distinct chains · 15% helix, 38% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | TAX1-binding protein 3 | protein | 103 | 16% helix, 39% strand | O14907 |
| B, D | Decameric peptide ICAL36 | protein | 10 | 0% helix, 30% strand | — |
| C | TAX1-binding protein 3 | protein | 104 | 15% helix, 38% strand | O14907 |
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 120 | 0.40 | 0.75 | 26 | empty |
Interfaces
3 interfaces between chains.
- A–B · 616 Ų buried · 14 hydrogen bonds · protein-protein
- C–D · 613 Ų buried · 11 hydrogen bonds · protein-protein
- A–C · 390 Ų buried · 5 hydrogen bonds · protein-protein
Compared structures
- 3SFJ · Crystal Structure of Tax-Interacting Protein-1 (TIP-1) PDZ domain bound to iCAL36… · the same entry in another collection · chain A against A, TM-score 1.00
- O14907 · AlphaFold monomer V2.0 prediction for TAX1-binding protein 3 (O14907) · a predicted model of the same protein · chain A against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O14907
- Elsewhere: RCSB PDB 3SFJ · PDBe 3SFJ · UniProt O14907
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