Research workbench
Structural insights into thiol stabilization of dj-1
Analyse Structural insights into thiol stabilization of dj-1 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3SF8
- Type
- protein
- Length
- 377 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein dj-1
- EC
- 3.4.-.-
- UniProt
- Q99497
- Pockets
- 3 · best druggability 0.56
Structure
x-ray diffraction · 2 distinct chains · 42% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Protein dj-1 (EC 3.4.-.-) | protein | 190 | 42% helix, 21% strand | Q99497 |
| B | Protein dj-1 (EC 3.4.-.-) | protein | 187 | 43% helix, 21% strand | Q99497 |
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 166 | 0.56 | 0.81 | 26 | empty |
| 2 | 103 | 0.39 | 0.76 | 20 | empty |
| 3 | 88 | 0.37 | 0.76 | 20 | empty |
Interfaces
1 interface between chains.
- A–B · 1405 Ų buried · 27 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 modified (oxidation).
Compared structures
- 3SF8 · Structural insights into thiol stabilization of DJ-1 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q99497
- Elsewhere: RCSB PDB 3SF8 · PDBe 3SF8 · UniProt Q99497
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.