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Crystal structure of the complex between the conserved cell polarity proteins inscuteable and lgn

Analyse Crystal structure of the complex between the conserved cell polarity proteins… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3SF4
Type: protein
Length: 1,183 residues
Chains: 6
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: G-protein-signaling modulator 2; Protein inscuteable homolog
UniProt: P81274, Q1MX18
Pockets: 17 · best druggability 0.74

Structure

x-ray diffraction · 6 distinct chains · 78% helix, 2% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	G-protein-signaling modulator 2	protein	355	83% helix, 0% strand	P81274
B	G-protein-signaling modulator 2	protein	350	83% helix, 0% strand	P81274
C	G-protein-signaling modulator 2	protein	346	86% helix, 0% strand	P81274
D	Protein inscuteable homolog	protein	45	29% helix, 18% strand	Q1MX18
E	Protein inscuteable homolog	protein	41	24% helix, 15% strand	Q1MX18
F	Protein inscuteable homolog	protein	46	28% helix, 17% strand	Q1MX18

Pockets

17 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	713	0.74	0.79	76	empty
2	110	0.55	0.83	19	empty
3	60	0.52	0.86	15	empty
4	77	0.52	0.84	14	empty
5	152	0.51	0.79	27	empty

Interfaces

8 interfaces between chains.

A–D · 2227 Å² buried · 37 hydrogen bonds · protein-protein
C–F · 2173 Å² buried · 38 hydrogen bonds · protein-protein
B–E · 2106 Å² buried · 38 hydrogen bonds · protein-protein
A–B · 772 Å² buried · 18 hydrogen bonds · protein-protein
A–E · 167 Å² buried · 0 hydrogen bonds · protein-protein

Compared structures

3SF4 · Crystal structure of the complex between the conserved cell polarity proteins Inscuteable… · the same entry in another collection · chain F against F, TM-score 1.00
P81274 · AlphaFold monomer V2.0 prediction for G-protein-signaling modulator 2 (P81274) · a predicted model of the same protein · chain B against A, TM-score 0.96
Q1MX18 · AlphaFold monomer V2.0 prediction for protein inscuteable homolog (Q1MX18) · a predicted model of the same protein · chain E against A, TM-score 0.59

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P81274
Every structure of UniProt Q1MX18
Elsewhere: RCSB PDB 3SF4 · PDBe 3SF4 · UniProt P81274 · UniProt Q1MX18

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