Research workbench

Human BCL-2, isoform 2

Analyse Human BCL-2, isoform 2 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1GJH
Type: protein
Length: 164 residues
Chains: 1
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Protein (apoptosis regulator BCL-2 with putative flexible loop replaced with a portion of…
UniProt: P10415, Q07817
Pockets: 1 · best druggability 0.36

Structure

solution nmr · 1 distinct chain · 61% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Protein (apoptosis regulator BCL-2 with putative flexible loop replaced with a portion of apoptosis regulator BCL-X protein)	protein	164	61% helix, 0% strand	P10415, Q07817

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	52	0.36	0.79	17	empty

Compared structures

1GJH · Human BCL-2, isoform 2 · the same entry in another collection · chain A against A, TM-score 1.00
P10415 · AlphaFold monomer V2.0 prediction for apoptosis regulator BCL-2 (P10415) · a predicted model of the same protein · chain A against A, TM-score 0.82
Q07817 · AlphaFold monomer V2.0 prediction for BCL-2-like protein 1 (Q07817) · a predicted model of the same protein · chain A against A, TM-score 0.81

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P10415
Every structure of UniProt Q07817
Elsewhere: RCSB PDB 1GJH · PDBe 1GJH · UniProt P10415 · UniProt Q07817

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