Research workbench
Human IFNA2-ifnar ternary complex
Analyse Human IFNA2-ifnar ternary complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3SE3
- Type
- protein
- Length
- 596 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Interferon ALPHA/BETA receptor 1; Interferon alpha 2B; Interferon ALPHA/BETA receptor 2
- UniProt
- P17181, Q86UP4, P48551
- Ligands
- NAG
- Pockets
- 11 · best druggability 0.72
Structure
x-ray diffraction · 3 distinct chains · 21% helix, 35% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Interferon ALPHA/BETA receptor 1 | protein | 285 | 7% helix, 41% strand | P17181 |
| B | Interferon alpha 2B | protein | 128 | 77% helix, 0% strand | Q86UP4 |
| C | Interferon ALPHA/BETA receptor 2 | protein | 183 | 4% helix, 50% strand | P48551 |
Ligands and binding sites
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
11 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 214 | 0.72 | 0.88 | 39 | empty |
| 2 | 271 | 0.71 | 0.85 | 41 | empty |
| 3 | 581 | 0.66 | 0.76 | 57 | empty |
| 4 | 226 | 0.58 | 0.80 | 30 | empty |
| 5 | 186 | 0.52 | 0.78 | 23 | empty |
Interfaces
2 interfaces between chains.
- A–B · 1046 Ų buried · 7 hydrogen bonds · protein-protein
- B–C · 932 Ų buried · 10 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 7 disulfide (disulfide).
Compared structures
- 3SE3 · human IFNa2-IFNAR ternary complex · the same entry in another collection · chain A against A, TM-score 1.00
- P48551 · AlphaFold monomer V2.0 prediction for interferon ALPHA/BETA receptor 2 (P48551) · a predicted model of the same protein · chain C against A, TM-score 0.94
- P17181 · AlphaFold monomer V2.0 prediction for interferon ALPHA/BETA receptor 1 (P17181) · a predicted model of the same protein · chain A against A, TM-score 0.92
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P17181
- Every structure of UniProt Q86UP4
- Every structure of UniProt P48551
- Elsewhere: RCSB PDB 3SE3 · PDBe 3SE3 · UniProt P17181 · UniProt Q86UP4 · UniProt P48551
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