Research workbench
The focal adhesion targeting (fat) domain of the focal adhesion kinase showing N-terminal interactions in cis
Analyse The focal adhesion targeting (fat) domain of the focal adhesion kinase showing… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3S9O
- Type
- protein
- Length
- 423 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Focal adhesion kinase 1
- EC
- 2.7.10.2
- UniProt
- Q05397
- Ligands
- NA, CL
- Pockets
- 7 · best druggability 0.48
Structure
x-ray diffraction · 3 distinct chains · 77% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Focal adhesion kinase 1 (EC 2.7.10.2) | protein | 141 | 77% helix, 0% strand | Q05397 |
| B | Focal adhesion kinase 1 (EC 2.7.10.2) | protein | 141 | 78% helix, 0% strand | Q05397 |
| C | Focal adhesion kinase 1 (EC 2.7.10.2) | protein | 141 | 76% helix, 0% strand | Q05397 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
7 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 82 | 0.48 | 0.82 | 17 | empty |
| 2 | 100 | 0.48 | 0.81 | 21 | CL |
| 3 | 148 | 0.42 | 0.75 | 22 | empty |
| 4 | 88 | 0.37 | 0.76 | 12 | empty |
| 5 | 90 | 0.37 | 0.75 | 13 | empty |
Interfaces
2 interfaces between chains.
- B–C · 691 Ų buried · 5 hydrogen bonds · protein-protein
- A–B · 669 Ų buried · 4 hydrogen bonds · protein-protein
Compared structures
- 3S9O · The Focal Adhesion Targeting (FAT) domain of the Focal Adhesion Kinase showing N-terminal… · the same entry in another collection · chain A against A, TM-score 1.00
- Q05397 · AlphaFold monomer V2.0 prediction for focal adhesion kinase 1 (Q05397) · a predicted model of the same protein · chain C against A, TM-score 0.94
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q05397
- Elsewhere: RCSB PDB 3S9O · PDBe 3S9O · UniProt Q05397
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