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Structure of Fab fragment of malaria transmission blocking antibody 2A8 against P. vivax P25 protein

Analyse Structure of Fab fragment of malaria transmission blocking antibody 2A8 against… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3S62
Type: protein
Length: 426 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Fab fragment of antibody 2A8, light chain; Fab fragment of antibody 2A8, heavy chain
Pockets: 10 · best druggability 0.66

Structure

x-ray diffraction · 2 distinct chains · 3% helix, 37% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
L	Fab fragment of antibody 2A8, light chain	protein	211	3% helix, 37% strand	—
H	Fab fragment of antibody 2A8, heavy chain	protein	215	3% helix, 37% strand	—

Pockets

10 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	72	0.66	0.93	20	empty
2	141	0.56	0.82	24	empty
3	161	0.47	0.77	22	empty
4	56	0.40	0.81	15	empty
5	116	0.38	0.74	21	empty

Interfaces

1 interface between chains.

L–H · 1809 Å² buried · 21 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 disulfide (disulfide).

Compared structures

3S62 · Structure of Fab fragment of malaria transmission blocking antibody 2A8 against P. vivax… · the same entry in another collection · chain L against L, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 3S62 · PDBe 3S62

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