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Structure of fanci

Analyse Structure of fanci in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3S51
Type: protein
Length: 4,373 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Fanconi anemia group I protein homolog
UniProt: Q8K368
Pockets: 20 · best druggability 0.78

Structure

x-ray diffraction · 3 distinct chains · 72% helix, 1% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, C	Fanconi anemia group I protein homolog	protein	1134	73% helix, 1% strand	Q8K368
B	Fanconi anemia group I protein homolog	protein	1071	73% helix, 1% strand	Q8K368
D	Fanconi anemia group I protein homolog	protein	1034	72% helix, 1% strand	Q8K368

Pockets

20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	826	0.78	0.81	84	empty
2	688	0.77	0.82	82	empty
3	88	0.76	0.97	26	empty
4	189	0.75	0.91	30	empty
5	210	0.74	0.90	36	empty

Interfaces

6 interfaces between chains.

C–D · 2152 Å² buried · 26 hydrogen bonds · protein-protein
A–B · 2113 Å² buried · 25 hydrogen bonds · protein-protein
B–D · 1327 Å² buried · 5 hydrogen bonds · protein-protein
A–C · 1320 Å² buried · 4 hydrogen bonds · protein-protein
A–D · 598 Å² buried · 8 hydrogen bonds · protein-protein

Compared structures

3S51 · Structure of FANCI · the same entry in another collection · chain D against D, TM-score 1.00
Q8K368 · AlphaFold monomer V2.0 prediction for fanconi anemia group I protein homolog (Q8K368) · a predicted model of the same protein · chain D against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8K368
Elsewhere: RCSB PDB 3S51 · PDBe 3S51 · UniProt Q8K368

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